Tumor-promoting Agents from Croton tigliumL. and Their Mode of Action1
نویسندگان
چکیده
The isolation of chemically pure tumor-promoting agents from croton oil in this laboratory facilitated the exploration of a number of areas concerning their mode of action and the role of tumor-promoting agents in chemical carcinogenesis. Our recent studies have centered on the mode of action of these phorbol esters on cellular and intracellular membranes. The use of tumor-promoting agents in two areas of carcinogenesis studies are also described in this report. They are: inhibition of tumorigenesis in two-stage carcinogenesis and the relationship between initiating agents, mutagens, and carcinogens.
منابع مشابه
Tumor-promoting agents from Croton tiglium L. and their mode of action.
The isolation of chemically pure tumor-promoting agents from croton oil in this laboratory facilitated the exploration of a number of areas concerning their mode of action and the role of tumor-promoting agents in chemical carcinogenesis. Our recent studies have centered on the mode of action of these phorbol esters on cellular and intracellular membranes. The use of tumor-promoting agents in t...
متن کاملThe effects of selected tumor-promoting agents and their nonpromoting analogs on DNA repair synthesis were examined in human diploid fibroblasts (WI-38) damaged
The effects of selected tumor-promoting agents and their nonpromoting analogs on DNA repair synthesis were examined in human diploid fibroblasts (WI-38) damaged with N-acetoxy-2-acetylaminofluorene. Over a range of doses, three promoters (croton oil, 12-O-tetradecanoyl phorbol13-acetate, and anthralin) were found to inhibit DNA repair synthesis while their nonpromoting analogs (phorbol and 1,8-...
متن کاملThe Tumor - enhancing Principles of Croton tiglium L . IL A Comparative Study 1
Distinct differences were observed in the biologic response elicited by the promoting agents croton resin and its active frac tions on the one hand and croton oil on the other. With the active fractions of croton resin, in initiation-promotion experiments, there is a high incidence of malignancy and a low incidence of tumor regression. Applied alone, croton resin gives rise to very few tumors. ...
متن کاملStudies on the mechanism of skin tumor promotion.
34). Clayson (8) has pointed out that “. . . promoting agents must act by bringing about an increase in the number of precancerous or cancerous cells compared with the number of normal cells. . . .“While this selection for initiated cells may be accomplished in several different ways, a molecular basis for the selection is suggested based on the experiments described here. The process of pr...
متن کاملThe tumor-enhancing principles of Croton tiglium L. II. A comparative study.
Distinct differences were observed in the biologic response elicited by the promoting agents croton resin and its active frac tions on the one hand and croton oil on the other. With the active fractions of croton resin, in initiation-promotion experiments, there is a high incidence of malignancy and a low incidence of tumor regression. Applied alone, croton resin gives rise to very few tumors. ...
متن کامل